World-renowned scientists are on the verge of curing genetic heart disease for the first time in history

The well-being

oi-Shivangi Karn

In groundbreaking new research, scientists will rewrite DNA to create the world’s first cure for genetic heart disease, at a “watershed moment” for cardiovascular medicine.

The world renowned scientists from UK, USA and Singapore have collaborated in this CureHeart project to design a jab for heart patients. According to dispatches, the British Heart Foundation has granted a sum of 30 million euros for this life-saving project.

This will be the first time researchers have used precision genetic techniques, known as base editing and master editing, in the heart to design and test the first cure for inherited heart muscle diseases in the heart. purpose of silencing defective genes.

Take a look at the details.

What are hereditary heart diseases?

Hereditary heart disease is an umbrella term that encompasses all heart disease passed down from parents to their children. They are also known as genetic heart diseases.

When one or both parents have a defective or mutated gene, there is a 50/50 chance of passing it on to children. Some of the inherited heart diseases are hypertrophic cardiomyopathy and high cholesterol.

Some people with inherited heart disease may not have many symptoms. The condition is diagnosed only after a sudden heart attack, fainting or sudden cardiac death. [1]

In the UK, around 500 young people die each year from genetic heart disease. Additionally, the disease affects approximately 0.8-1.2% of newborn babies worldwide. [2]

Genetic heart disease could be cured

About Research

An advisory committee chaired by Professor Sir Patrick Vallance, who is the UK government’s chief scientific adviser, chose the team behind the latest research. Another professor, Hugh Watkins, who is from the University of Oxford and who is also the principal investigator of CureHeart, talked about cardiomyopathies saying that it is a really “common” disease all over the world. and is known to affect one in 250 people.

“This is our unique opportunity to relieve families of the constant worry of sudden death, heart failure and the potential need for a heart transplant,” he said. Watkins added: “After 30 years of research, we have discovered many specific genes and genetic defects responsible for different cardiomyopathies and how they work. We believe we will have gene therapy ready to begin clinical trials within the next five years. “

It is hoped that the new research program will permanently correct the mutated genes responsible for heart problems.

A Harvard Medical School professor and co-lead of the project, Christine Seidman, said the goal was to “repair hearts” and restore them to normal functioning.

“Most of the mutations we find in our human patients – and there are many – all frequently change a single letter of the DNA code. This raised the possibility that we could change a single letter and restore the code so that it is correct,” she said.

What are the chances of success with CureHeart?

According to the study researchers, they have not yet conducted human trials, but animal trials have been successful and promising.

Additionally, in research, pioneers from around the world who are experts in gene editing and related techniques have come together, making the mission a world-class effort to cure inherited heart diseases.

“We enlisted pioneers of the new ultra-precise gene editing, as well as technical experts, to ensure that our genetic tools safely enter the heart.” Our initial dream should come true thanks to our world-class team from three continents.

Genetic heart disease could be cured

To conclude

According to experts, this gene therapy will be ready for human trials within the next five years. People at risk for inherited heart disease due to having faulty genes in their family may be able to receive a cure before their disease develops. It can also give relief to a family that their future generations are safe from the disease.

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