Risk of congenital heart defects in offspring of affected mothers and fathers

This article was originally published here

Circ Genom Precis Med. May 24, 2022: 101161CIRCGEN121003533. doi: 10.1161/CIRCGEN.121.003533. Online ahead of print.

ABSTRACT

BACKGROUND: Smaller studies have reported a higher risk of congenital heart defects (CHD) in mothers with coronary artery disease than in fathers with coronary artery disease. In a large population-based study, we investigated whether the risk of CAD in offspring differed for mothers and fathers with CAD.

Methods: All persons born in Denmark, from 1977 to 2011, with at least 1 registered parent, were included in our cohort (n=2,341,061). Parent-child CHD recurrence was assessed using relative risks (RRs) comparing the risks of CHD in individuals with and without a parent with CHD, estimated using binomial log-linear regression.

RESULTS: The RRs for any coronary heart disease in offspring were 5.39 (95% CI, 4.88-5.96) for dams and 3.04 (95% CI, 2.59-3, 57) for fathers with coronary heart disease; the ratio of RRs for mothers to fathers was 1.82 (P

CONCLUSIONS: The risks of coronary heart disease recurrence were significantly higher in the offspring of affected women than in the offspring of affected men. The excess risks of maternal recurrence could not be explained by the slightly higher birth rates among women with coronary artery disease.

PMID:35608601 | DOI:10.1161/CIRCGEN.121.003533