Mild congenital heart defects linked to cardiovascular events

(HealthDay)—People with adult-onset congenital heart disease of lesser complexity have a higher burden of adverse cardiovascular events than the general population, independent of conventional cardiovascular risk factors, according to a study published Feb. 28 in Traffic.

Priyanka Saha of Stanford University School of Medicine in California and colleagues attempted to quantify the risk of adverse cardiovascular events in 2,006 adults with lower complexity ACHD compared to 497,983 adults without ACHD (median age, 58 at enrollment) in the UK Biobank. . Follow-up data was available up to 22 years.

Researchers found that of those with ACHD, 69% were also diagnosed or treated for hypertension, 41% were diagnosed or treated for hyperlipidemia, and 7% were diagnosed or treated for diabetes. ACHD remained strongly associated with fatal and nonfatal acute coronary syndrome (ACS), ischemic stroke, heart failure (HF), and atrial fibrillation, even after adjusting for 12 cardiovascular risk factors (the hazard ratios ranged from 2 for ACS to 13 for IC). Individuals exposed to ACHD with no more than two cardiovascular risk factors had an age-adjusted incidence rate of 29% of major adverse cardiovascular events compared to 13% in individuals without ACHD presenting at least least five risk factors.

“These findings underscore the need for closer monitoring of patients with mild to moderate ACHD and further investigation of cardiovascular risk management and mechanisms unique to this growing population of high-risk adults,” write the authors.


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