AHA and Children’s Heart Foundation provide funding for research into congenital heart defects

February 13, 2021

2 minutes to read

Disclosures: Elkind and Slawin do not report any relevant financial disclosures.

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The American Heart Association and the Children’s Heart Foundation have announced that they have committed $ 917,426 to advance research into congenital heart defects.

The funding represents the eighth round of a commitment. The groups have pledged $ 14.3 million to fund research into congenital heart defects over 10 years, according to a press release.

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Mitchell SV Elkind

“By funding research directly related to the advancement of prevention, we are investing essential resources so that more children can survive into healthy adulthood,” Mitchell SV Elkind, MD, MS, FAHA, FAAN, president of the AHA, professor of neurology and epidemiology at Columbia University Irving Medical Center and attending neurologist at NewYork-Presbyterian Hospital, said in the statement. “Research is the foundation of the American Heart Association. Supporting innovative research saves and improves the lives of children, and that is of the utmost importance to us.

In the eighth cycle of the Congenital Heart Defects Fellowship Program, funding will be divided among eight research projects nationwide. Funding has been allocated to:

  • Barbara gonzalez teran, PhD, postdoctoral fellow in cardiovascular biology at the Gladstone Institutes of the J. David Gladstone Institutes in San Francisco, for his work on the exploration of the deregulation of interactions between two genes encoding a protein by a congenital variant associated with a heart defect and its impact on cardiac development;
  • Benjamin streeter, doctoral student at Emory University, for his work on electrospun patches based on polycaprolactone, a tissue compatible biomaterial, to improve the repair potential of cardiac progenitor cells;
  • Dulguun Amgalan, doctorate, postdoctoral researcher in genetics at Stanford University School of Medicine, for his work on regulatory maps of endothelial cell differentiation to link risk variants of congenital heart disease to target genes;
  • Mingkun Wang, PhD, postdoctoral fellow at the Meinig School of Biomedical Engineering at Cornell University, for his work on the mechanical regulation of YAP / TAZ activity, proteins that shuttle between the cytoplasm and the nucleus in response to multiple inputs, in the growth and maturation of the atrioventricular valve;
  • Devin Laurence, a graduate research assistant at the University of Oklahoma in Norman, Oklahoma, for his work on in silico guided assessment and management of tricuspid regurgitation in patients with hypoplastic left heart syndrome;
  • Sathiyanarayanan Manivannan, doctorate, a postdoctoral researcher at the Nationwide Children’s Hospital Research Institute in Columbus, Ohio, for his work on the developmental origins of hypoplastic left heart syndrome examined using genetically related RBFOX2 variants;
  • Alexis Leigh Krup, doctoral student at the University of California, San Francisco, for his work on the specification of dissection of cardiac precursor cells at single cell resolution; and
  • Jennifer klein, MD, FAAP, a pediatrician at the Children’s National Medical Center and the Children’s Research Institute in Washington, DC, for his work mapping the geographic distribution of congenital heart disease and associated neurological findings.

“At the Children’s Heart Foundation, funding the most promising research in congenital heart disease is our only mission. Kevin slawin, chairman of the board of directors of the Children’s Heart Foundation, said in the statement. “Through this collaboration and our continued commitment to this important work, we strive to have a lasting impact on the lives of patients with congenital heart disease and their families. “

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